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KMID : 0359119760080010001
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Korean Journal of Gastroenterology
1976 Volume.8 No. 1 p.1 ~ p.8
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Effects of Antitumor Agents (BCG, Tubercin-3, OK-432 and H-11 extract) on Gastric and Pancreatic Secretion in Rats
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金源准/KIm, W.J.
安英秀/鄭泰浩/許渤景/洪思奭/Ahn, Y.S./Chung, T.H/Hur, K.B./Hong, S.S.
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Abstract
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The anti-tumor activity of BCG has been demonstrated by the inhibition of tumor growth in animals previously infected with viable organism or treated with non-viable mycobacterial pro-ducts. Protein extract of mycobacterium, Tubercin-3, and lyophilized preparation of streptococcus hemolyticus, OK-432, have also been shown to have the tumor inhibiting effects and along with BCG these are used as cancer immunotherapeutics. H-11 extract, obtained from human urine, was discovered during the investigation of the innate mechanism of animals against cancer and is also used to treat cancer as a tumor inhibitory principle.
We studied the effects of the four agents(BCG, Tubercin-3, OK-432 and H-11 extract) with large doses on secretory function of stomach and pancreato-biliary system in rats. The following results were obtained;
1. With the administration of a large dose of BCG or H-11 extract, the volume of gastric secretion as well as acid output are depressed. In contrast, after administration of Tubercin-3 or OK 432, gastric acid concentrations are elevated, but without changes in gastric juice volume or acid output. Gastric pH is lowered only in the group to which Tubercin-3 was administered.
2. After a single injection of a large dose, BCG and Tubercin-3 increase the bilirubin output, OK-432 decreases volume and increases the bilirubin concentration, and H-11 extract decreases the volume and increases the bilirubin output of the pancreato-biliary juice, but no groups show any significant changes in cholate secretion. In the groups receiving long term treatment, only the OK-432 group shows decreased volume and bilirubin output, and increased cholate concentration.
3. Tubercin-3 increases lipase activity following a single injection, but this effect was not significant after long term treatment. After long term treatment with OK-432, decreased lipase and amylase activities are revealed, but no significant changes are observed after a single injection. With the administration of BCG or H-11 extract, there is no changes in lipase or amylase activity.
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